Open federal opportunity · PAR-25-145

Clinical Characterization of Cancer Therapy-induced Adverse Sequelae and Mechanism-based Interventional Strategies (R01 Clinical Trial Optional)

National Institutes of Health lists this opportunity for nonprofit applicant type listed. Review the coded eligibility, award range, source synopsis, and official notice before deciding whether to apply.

EducationHealth

Deadline

January 7, 2028

443 days remaining

Award range

—

official range may be incomplete

Applicant signal

Nonprofit applicant type listed

the official notice controls eligibility

Official synopsis

The purpose of this Funding Opportunity Announcement (FOA) is to support collaborative research projects designed to address adverse sequelae of cancer therapies that persist and become chronic comorbidities or develop as delayed posttreatment effects. This FOA supports basic, translational, and clinical research projects that seek to identify the mechanisms of therapy-induced adverse sequelae, clinically characterize the adverse sequelae, or translate the mechanistic understanding into therapeutic approaches to prevent or minimize the development of long-term sequelae. Research projects should focus on mechanistic studies with translational endpoints and longitudinal clinical phenotyping to identify and validate clinical endpoints (biomarkers, imaging, patient-reported outcomes, or combined elements) for future use in clinical trials that will evaluate the efficacy of interventions designed to prevent or reduce specific adverse sequelae.

Open the official Grants.gov listing ↗

Coded applicant types
  • 00 — State governments
  • 01 — County governments
  • 02 — City or township governments
  • 04 — Special district governments
  • 05 — Independent school districts
  • 06 — Public and state-controlled institutions of higher education
  • 07 — Federally recognized Native American tribal governments
  • 08 — Public housing authorities and Indian housing authorities
  • 11 — Native American tribal organizations other than federally recognized tribal governments
  • 12 — 501(c)(3) nonprofits other than institutions of higher education
  • 13 — Nonprofits without 501(c)(3) status other than institutions of higher education
  • 20 — Private institutions of higher education
  • 22 — For-profit organizations other than small businesses
  • 23 — Small businesses
  • 25 — Other applicants; see the official eligibility clarification

These are high-level Grants.gov codes. Additional eligibility text, geographic restrictions, and program-specific rules in the official notice can narrow them.

Before investing application time
  1. Confirm entity eligibility in the full Notice of Funding Opportunity.
  2. Check SAM.gov and Grants.gov registration requirements and timing.
  3. Read every attachment for matching, cost-share, geography, and award conditions.
  4. Verify the exact deadline time and any agency-specific submission portal.
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Source: Grants.gov daily XML extract, 2026-10-21 extract. This page reproduces selected public listing fields for research convenience. The official Notice of Funding Opportunity and agency instructions control. This product uses the Grants.gov API but is not endorsed or certified by the U.S. Department of Health and Human Services.