Open federal opportunity · PAR-25-101

Cutting-Edge Basic Research Awards (CEBRA) (R21 Clinical Trial Optional)

National Institutes of Health lists this opportunity for nonprofit applicant type listed. Review the coded eligibility, award range, source synopsis, and official notice before deciding whether to apply.

EducationHealth

Deadline

August 11, 2027

294 days remaining

Award range

up to $150,000

$150,000 estimated program funding

Applicant signal

Nonprofit applicant type listed

the official notice controls eligibility

Official synopsis

The National Institute on Drug Abuse (NIDA) Cutting-Edge Basic Research Award (CEBRA) is designed to foster highly innovative or conceptually creative research related to the etiology, pathophysiology, prevention, or treatment of substance use disorders (SUDs). It supports high-risk and potentially high-impact research that is sparse or not included in NIDA's current portfolio that has the potential to transform SUD research. The proposed research should: 1. develop, and/or adapt, revolutionary techniques or methods for addiction research or that show promising future applicability to SUD research; and /or 2. test an innovative and significant hypothesis for which there are scant precedent or preliminary data and which, if confirmed, would transform current thinking.

Open the official Grants.gov listing ↗

Coded applicant types
  • 00 — State governments
  • 01 — County governments
  • 02 — City or township governments
  • 04 — Special district governments
  • 05 — Independent school districts
  • 06 — Public and state-controlled institutions of higher education
  • 07 — Federally recognized Native American tribal governments
  • 08 — Public housing authorities and Indian housing authorities
  • 11 — Native American tribal organizations other than federally recognized tribal governments
  • 12 — 501(c)(3) nonprofits other than institutions of higher education
  • 13 — Nonprofits without 501(c)(3) status other than institutions of higher education
  • 20 — Private institutions of higher education
  • 22 — For-profit organizations other than small businesses
  • 23 — Small businesses
  • 25 — Other applicants; see the official eligibility clarification

These are high-level Grants.gov codes. Additional eligibility text, geographic restrictions, and program-specific rules in the official notice can narrow them.

Before investing application time
  1. Confirm entity eligibility in the full Notice of Funding Opportunity.
  2. Check SAM.gov and Grants.gov registration requirements and timing.
  3. Read every attachment for matching, cost-share, geography, and award conditions.
  4. Verify the exact deadline time and any agency-specific submission portal.
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Source: Grants.gov daily XML extract, 2026-10-21 extract. This page reproduces selected public listing fields for research convenience. The official Notice of Funding Opportunity and agency instructions control. This product uses the Grants.gov API but is not endorsed or certified by the U.S. Department of Health and Human Services.